review high-performance liquid chromatographic enantioseparation of drugs containing multiple chiral centers on chiral stationary phases

Review High-performance liquid chromatographic enantioseparation of drugs containing multiple chiral centers on chiral stationary phases

In recent years there has been considerable interest in the synthesis and separation of enantiomers of organic compounds especially because of their importance in the biochemistry and pharmaceutical industry. High-performance liquid Chromatography is a very useful method for the direct separation of enantiomers. However, about 30−40 years ago, commercially available chiral stationary phases wer...

High-performance liquid chromatographic enantioseparation of drugs containing multiple chiral centers on chiral stationary phases

In recent years there has been considerable interest in the synthesis and separation of enantiomers of organic compounds especially because of their importance in the biochemistry and pharmaceutical industry. High-performance liquid Chromatography is a very useful method for the direct separation of enantiomers. However, about 30−40 years ago, commercially available chiral stationary phases wer...

HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC ENANTIOSEPARATION OF UNNATURAL -AMINO ACIDS ON CHIRAL STATIONARY PHASES Summary of PhD Thesis

Enantioseparation using amylose esters as chiral stationary phases for high-performance liquid chromatography

Novel amylose ester derivatives were synthesized and their chiral recognition abilities as chiral stationary phases for highperformance liquid chromatography were evaluated. Compared with amylose benzoate derivatives, cinnamate derivatives showed a higher chiral recognition ability and some racemates could be efficiently resolved. The recognition abilities of these derivatives varied significan...

High-performance Liquid Chromatographic Separation of the Enantiomers of Amino Compounds on Chiral Stationary Phases

Enantioseparation of aldols by high-performance liquid chromatography on polysaccharide-based chiral stationary phases that bear chlorinated substituents.

Two families of aldols, obtained from the condensation of aromatic aldehydes with cyclohexanone or acetone (ten examples in each group), were analyzed by high-performance liquid chromatography in normal phase elution mode on three polysaccharide-based chiral stationary phases of the Lux series, namely, Lux Cellulose-2, Lux Cellulose-4 and Lux Amylose-2, which share the common feature of chlorin...